XLVIII.—Attempts to prepare asymmetric quinquevalent nitrogen compounds. Part I. 5-Aminosalicylic acid and related compounds

Duration of treatment with 5-aminosalicylic acid compounds.

The development of 5-aminosalicylic acid (5-ASA) therapy as a life long treatment for ulcerative colitis is reviewed from its origins in the 1940s to the present day. The drug was designed to treat rheumatoid arthritis, but was found helpful in the management of nine patients with ulcerative colitis. This discovery preceded the emergence of the clinical trial as a tool for assessing a new drug'...

Pteroylglutamic acid and related compounds.

Studies on Uric Acid and Related Compounds

The systematic study of the substrate specificity of mammalian xanthine oxidase has indicated a common mechanism by which various purines may be dehydrogenated (1). The results obtained also made it clear why methylated xanthines, with the exception of 1-methylxanthine (2), cannot be oxidized by xanthine oxidase to the corresponding substituted uric acids (3, 4). Therefore, another source had t...

Acid hydrolysis of colchicine and related compounds.

Acid-catalyzed hydrolysis of the methox-ytropone moiety of colchicine has been shown to proceed at a greater rate than in the case of isocolchicine1. (Struc­ tures are shown in Table I.) No interpretation of this rate difference has been offered. And, while a mecha­ nism for the acid-catalyzed hydrolysis of 2 -methoxytropone has been proposed2, no kinetic data on this type of reaction either fo...

Greenhouse Experiments with Atmospheric Nitrogen Fertilizers and Related Compounds

In connection with a study at the Fixed Nitrogen Research Laboratory on the possible transformation products of cyanamid, there was obtained a number of materials and mixtures concerning which there is either very little known, or concerning which there is still some doubt as to their fertilizing value. Thus, in the preparation of urephos, a product was obtained in which approximately 55 per ce...